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The sedative–hypnotic activity of methaqualone was first noted in the 1950s. In 1962, methaqualone was patented in the UK by Wallace and Tiernan. Its use peaked in the early 1970s for the treatment of insomnia, and as a sedative and muscle relaxant.

Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as “ludes” or “sopers” (also “soaps”) in the U.S. and “mandrakes” and “mandis” in the UK, Australia and New Zealand. The substance was sold both as a free base and as salt (hydrochloride). It is also a common date rape drug.

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Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity is increased, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia.[3] Methaqualone peaks in the bloodstream within several hours, with a half-life of 20–60 hours. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma and death.

Methaqualone was not recommended for use while pregnant and is in pregnancy category D

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In 1972, it was the sixth-bestselling sedative in the US, where it was legal under the brand name Quaalude. The drug name “Quaalude” combined the words “quiet interlude” and shared a stylistic reference to another drug marketed by the firm, Maalox. Best Place To Order Or Buy Quaalude or Mandrax For Sale with bitcoin prior no prescription

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